| http://purl.uniprot.org/citations/25092144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25092144 | http://www.w3.org/2000/01/rdf-schema#comment | "Almost 30% of all acute myeloid leukemias (AML) are associated with an internal tandem duplication (ITD) in the juxtamembrane domain of FMS-like tyrosine kinase 3 receptor (FLT3). Patients with FLT3-ITD mutations tend to have a poor prognosis. MicroRNAs (miRNAs) have a pivotal role in myeloid differentiation and leukemia. MiRNA-155 (MiR-155) was found to be upregulated in FLT3-ITD-associated AMLs. In this study, we discovered that FLT3-ITD signaling induces the oncogenic miR-155. We show in vitro and in vivo that miR-155 expression is regulated by FLT3-ITD downstream targets nuclear factor-κB (p65) and signal transducer and activator of transcription 5 (STAT5). Further, we demonstrate that miR-155 targets the myeloid transcription factor PU.1. Knockdown of miR-155 or overexpression of PU.1 blocks proliferation and induces apoptosis of FLT3-ITD-associated leukemic cells. Our data demonstrate a novel network in which FLT3-ITD signaling induces oncogenic miR-155 by p65 and STAT5 in AML, thereby targeting transcription factor PU.1."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2014.231"xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Duyster J."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Muller-Tidow C."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Madan V."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Behre G."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Gerloff D."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Wurm A.A."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Niederwieser D."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Grundler R."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Brauer-Hartmann D."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Hartmann J.U."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/author | "Katzerke C."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/pages | "535-547"xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/title | "NF-kappaB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/25092144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25092144 |
| http://purl.uniprot.org/citations/25092144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25092144 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-25092144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25092144 |
| http://purl.uniprot.org/uniprot/#_A8K6I5-mappedCitation-25092144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25092144 |
| http://purl.uniprot.org/uniprot/#_A0A384N5W4-mappedCitation-25092144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25092144 |