| http://purl.uniprot.org/citations/25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25094062 | http://www.w3.org/2000/01/rdf-schema#comment | "High temperature requirement A2 (HtrA2)/Omi is a serine protease localized in mitochondria. In response to apoptotic stimuli, HtrA2 is released to the cytoplasm and cleaves many proteins, including XIAP, Apollon/BRUCE, WT1, and Ped/Pea-15, to promote apoptosis. However, the function of HtrA2 in mitochondria under normal conditions remains unclear. Here, we show that the mitochondrial proteins, LON protease 1 (LONP1) and prohibitin (PHB), are overexpressed in HtrA2(-/-) mouse embryonic fibroblast (MEF) cells and HtrA2 knock-down HEK293T cells. We also confirm the effect of the HtrA2 protease on the stability of the above mitochondrial quality control proteins in motor neuron degeneration 2 (mnd2) mice, which have a greatly reduced protease activity as a result of a Ser276Cys missense mutation of the HtrA2 gene. In addition, PHB interacts with and is directly cleaved by HtrA2. Luminescence assays demonstrate that the intracellular ATP level is decreased in HtrA2(-/-) cells compared to HtrA2(+/+) cells. HtrA2 deficiency causes a decrease in the mitochondrial membrane potential, and reactive oxygen species (ROS) generation is greater in HtrA2(-/-) cells than in HtrA2(+/+) cells. Our results implicate that HtrA2 might be an upstream regulator of mitochondrial homeostasis."xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2014.07.032"xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/author | "Rhim H."xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/author | "Goo H.G."xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/pages | "456-465"xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/title | "HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis."xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://purl.uniprot.org/core/volume | "328"xsd:string |
| http://purl.uniprot.org/citations/25094062 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25094062 |
| http://purl.uniprot.org/citations/25094062 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25094062 |
| http://purl.uniprot.org/uniprot/#_D3YX27-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_D3YX28-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_A0A3B2W834-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_F6XUR8-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_F6TCV0-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_Q3TXN0-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_Q3V2D0-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_Q8CGK3-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_Q3UJR3-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_Q56A16-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_Q9JIY5-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |
| http://purl.uniprot.org/uniprot/#_Q80V84-mappedCitation-25094062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25094062 |