| http://purl.uniprot.org/citations/25100727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25100727 | http://www.w3.org/2000/01/rdf-schema#comment | "The bone morphogenetic protein (BMP) signaling pathway regulates a wide range of cellular responses in metazoans. A key step in the canonical BMP signaling is the phosphorylation and activation of transcription factors Smad1, Smad5, and Smad8 (collectively Smad1/5/8) by the type I BMP receptors. We previously identified PPM1A as a phosphatase toward dephosphorylation of all receptor-regulated Smads (R-Smads), including Smad1/5/8. Here we report another nuclear phosphatase named SCP4/CTDSPL2, belonging to the FCP/SCP family, as a novel Smad phosphatase in the nucleus. SCP4 physically interacts with and specifically dephosphorylates Smad1/5/8, and as a result attenuates BMP-induced transcriptional responses. Knockdown of SCP4 in multipotent mesenchymal C2C12 cells leads to increased expression of BMP target genes and consequently promotes BMP-induced osteogenic differentiation. Collectively, our results demonstrate that SCP4, as a Smad phosphatase, plays a critical role in BMP-induced signaling and cellular functions."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.568964"xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Sun B."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Xiao M."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Duan X."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Feng X.H."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Yu P.B."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/author | "Shen T."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/pages | "26441-26450"xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/title | "C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation."xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/25100727 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25100727 |
| http://purl.uniprot.org/citations/25100727 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25100727 |
| http://purl.uniprot.org/uniprot/Q8BG15#attribution-BD0DF476C3B5E316921E49DB6D4532E2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25100727 |
| http://purl.uniprot.org/uniprot/Q8BG15#attribution-C9C64F375DB9C07BC18BB3630C79E19F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25100727 |
| http://purl.uniprot.org/uniprot/P49443#attribution-BD0DF476C3B5E316921E49DB6D4532E2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25100727 |
| http://purl.uniprot.org/uniprot/P49443#attribution-C9C64F375DB9C07BC18BB3630C79E19F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25100727 |
| http://purl.uniprot.org/uniprot/P70340#attribution-C9C64F375DB9C07BC18BB3630C79E19F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25100727 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJZ4-mappedCitation-25100727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25100727 |