| http://purl.uniprot.org/citations/25101977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25101977 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular properties of leukemia stem cells (LSCs) are achieved at least through Class I and Class II mutations that generate signals for enhanced proliferation and impaired differentiation, respectively. Here we show that in t(8;21) acute myelogenous leukemia (AML), hematopoietic stem cells (HSCs) transform into LSCs via definitively-ordered acquisition of Class II (AML1/ETO) and then Class I (c-KIT mutant) abnormalities. Six t(8;21) AML patients with c-KIT mutants maintaining > 3 years of complete remission were analyzed. At diagnosis, all single LSCs had both AML1/ETO and c-KIT mutations. However, in remission, 16 out of 1,728 CD34(+)CD38(-) HSCs and 89 out of 7,187 single HSC-derived myeloerythroid colonies from these patients had AML1/ETO, whose breakpoints were identical to those found in LSCs. These cells had wild-type c-KIT, which expressed AML1/ETO at a low level, and could differentiate into mature blood cells, suggesting that they may be the persistent preleukemic stem cells. Microarray analysis suggested that mutated c-KIT signaling provides LSCs with enhanced survival and proliferation. Thus, in t(8;21) AML, the acquisition of AML1/ETO is not sufficient, and the subsequent upregulation of AML1/ETO and the additional c-KIT mutant signaling are critical steps for transformation into LSCs."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exphem.2014.07.267"xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Miyamoto T."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Iwasaki H."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Goto N."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Mizuno S."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Akashi K."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Shima T."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Takenaka K."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Kikushige Y."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Yoshimoto G."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Tochigi T."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/author | "Yuda J."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/name | "Exp Hematol"xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/pages | "955-65.e1-5"xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/title | "The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell."xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/25101977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25101977 |
| http://purl.uniprot.org/citations/25101977 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25101977 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSU1-mappedCitation-25101977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25101977 |
| http://purl.uniprot.org/uniprot/#_A0A0U2N547-mappedCitation-25101977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25101977 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG58-mappedCitation-25101977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25101977 |