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| http://purl.uniprot.org/citations/25103244 | http://www.w3.org/2000/01/rdf-schema#comment | "The Golgi apparatus is optimized separately in different tissues for efficient protein trafficking, but we know little of how cell signaling shapes this organelle. We now find that the Abl tyrosine kinase signaling pathway controls the architecture of the Golgi complex in Drosophila photoreceptor (PR) neurons. The Abl effector, Enabled (Ena), selectively labels the cis-Golgi in developing PRs. Overexpression or loss of function of Ena increases the number of cis- and trans-Golgi cisternae per cell, and Ena overexpression also redistributes Golgi to the most basal portion of the cell soma. Loss of Abl or its upstream regulator, the adaptor protein Disabled, lead to the same alterations of Golgi as does overexpression of Ena. The increase in Golgi number in Abl mutants arises in part from increased frequency of Golgi fission events and a decrease in fusions, as revealed by live imaging. Finally, we demonstrate that the effects of Abl signaling on Golgi are mediated via regulation of the actin cytoskeleton. Together, these data reveal a direct link between cell signaling and Golgi architecture. Moreover, they raise the possibility that some of the effects of Abl signaling may arise, in part, from alterations of protein trafficking and secretion."xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e14-02-0729"xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/author | "Wincovitch S."xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/author | "Kannan R."xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/author | "Giniger E."xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/author | "Kuzina I."xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/author | "Nowotarski S.H."xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/pages | "2993-3005"xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/title | "The Abl/enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons."xsd:string |
| http://purl.uniprot.org/citations/25103244 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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