| http://purl.uniprot.org/citations/25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25104389 | http://www.w3.org/2000/01/rdf-schema#comment | "Elongation factor 4 (EF4/LepA) is a highly conserved guanosine triphosphatase translation factor. It was shown to promote back-translocation of tRNAs on posttranslocational ribosome complexes and to compete with elongation factor G for interaction with pretranslocational ribosomes, inhibiting the elongation phase of protein synthesis. Here, we report a crystal structure of EF4-guanosine diphosphate bound to the Thermus thermophilus ribosome with a P-site tRNA at 2.9 angstroms resolution. The C-terminal domain of EF4 reaches into the peptidyl transferase center and interacts with the acceptor stem of the peptidyl-tRNA in the P site. The ribosome is in an unusual state of ratcheting with the 30S subunit rotated clockwise relative to the 50S subunit, resulting in a remodeled decoding center. The structure is consistent with EF4 functioning either as a back-translocase or a ribosome sequester."xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1253525"xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/author | "Steitz T.A."xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/author | "Bulkley D."xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/author | "Gagnon M.G."xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/pages | "684-687"xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/title | "Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome."xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://purl.uniprot.org/core/volume | "345"xsd:string |
| http://purl.uniprot.org/citations/25104389 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25104389 |
| http://purl.uniprot.org/citations/25104389 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25104389 |
| http://purl.uniprot.org/uniprot/P60785#attribution-7BECE061C3D3EF0D0FBABA84675F4F91 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P35871-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P0DOY6-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P0DOY7-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P0DOY8-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P0DOY9-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P17291-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P80339-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P80340-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P80371-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |
| http://purl.uniprot.org/uniprot/#_P80372-mappedCitation-25104389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25104389 |