| http://purl.uniprot.org/citations/25107697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25107697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25107697 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) is a pivotal receptor that detects numerous RNA and DNA viruses and mediates the innate induction of interferons and pro-inflammatory cytokines upon viral infection. In the present study, we cloned and characterized the first RIG-I gene in a marine mollusk, Crassostrea gigas, and designated it as CgRIG-I. The full-length CgRIG-I cDNA is 3436 bp, including 5'- and 3'-untranslated regions (UTRs) of 93 bp and 286 bp, respectively, and an open reading frame (ORF) of 3057 bp. The gene encodes a 1018 amino acid polypeptide with an estimated molecular mass of 116.5 kDa. SMART analysis showed that the CgRIG-I protein had the typical conserved domains, including the caspase activation and recruitment domains (CARDs), the RNA helicase domain and the C-terminal regulatory domain (RD). Phylogenetic analysis revealed that CgRIG-I was grouped into the clade of its vertebrate homologs. Moreover, CgRIG-I expression could be specifically increased after stimulation by poly(I:C) rather than by other PAMPs such as lipopolysaccharide (LPS), peptidoglycan (PGN), heat-killed Listeria monocytogenes (HKLM) and heat-killed Vibrio alginolyticus (HKVA). Meanwhile, six IRF, three STAT and one NF-κB predicted sites were identified in the CgRIG-I promoter, which was consistent with its high responsiveness to poly(I:C). In summary, this report provides the first CgRIG-I sequence of a mollusk, but its function in the antiviral immune response requires further investigation."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.fsi.2014.07.029"xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.fsi.2014.07.029"xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Tong Y."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Tong Y."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Yu F."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/author | "Yu F."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/name | "Fish Shellfish Immunol."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/name | "Fish Shellfish Immunol"xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/pages | "466-471"xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/pages | "466-471"xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/title | "The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas."xsd:string |
| http://purl.uniprot.org/citations/25107697 | http://purl.uniprot.org/core/title | "The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas."xsd:string |