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Objective

To observe the changes of mRNA and protein expressions of extracellular signal-regulated kinase 1/2 (ERK1/2) and matrix metalloproteinase 2 (MMP-2), MMP-9 in cervical cancer cells after stimulated by baicalein at different concentrations.

Methods

HeLa cells cultured in vitro were exposed to baicalein (0, 100 and 200 μmol/L) for 24 hours. The activity of MMP-2 and MMP-9 was measured by gelatin zymography, mRNA expressions of ERK1/2, MMP-2, MMP-9 were determined by reverse transcription PCR (RT-PCR) and protein expressions of ERK1/2, MMP-2, MMP-9 were detected by Western blotting.

Results

Compared with the control group, baicalein significantly decreased the activity of MMP-2 and MMP-9 in a concentration-dependent manner (P<0.05). The mRNA and protein expressions of ERK1/2, p-ERK1/2, MMP-2, MMP-9 also significantly decreased (P<0.05).

Conclusion

Baicalein can activate ERK1/2 signaling pathway and decreasing the activity of MMP-2 and MMP-9."xsd:string
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http://purl.uniprot.org/citations/25108429http://purl.uniprot.org/core/author"Xia J."xsd:string
http://purl.uniprot.org/citations/25108429http://purl.uniprot.org/core/author"Lu K."xsd:string
http://purl.uniprot.org/citations/25108429http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25108429http://purl.uniprot.org/core/name"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/25108429http://purl.uniprot.org/core/pages"798-801"xsd:string
http://purl.uniprot.org/citations/25108429http://purl.uniprot.org/core/title"[Baicalein induces HeLa cell growth inhibition by down-regulation of matrix metalloproteinases and activating extracellular signal-regulated kinase]."xsd:string
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