| http://purl.uniprot.org/citations/25113400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25113400 | http://www.w3.org/2000/01/rdf-schema#comment | "Renal cell carcinoma (RCC) represents approximately 2-3% of human malignancies. Nuclear transcription factor кB (NF-кB) is composed of a family of transcription factors that have been associated with the development and progression of RCC. Endostatin (ES) is a fragment of collagen XVIII that possesses antiangiogenic activity. In this study, we evaluated the expression of NF-кB in metastatic tumor cells from animals treated with ES. Balb/c-bearing Renca-EGFP cells were treated with NIH/3T3-LendSN or NIH/3T3-LXSN cells as a control. At the end of the in vivo experiment, plasma Renca-EGFP-sorted cells and tissue lung samples were collected. A real-time PCR array for NF-κB target genes revealed that ES therapy led to down regulation of Bcl-3 (P<0.031), NF-кB1 (P<0.001) and c-Rel (P<0.004) in the ES-treated group. Using an electrophoretic mobility shift assay (EMSA), we observed a reduction in NF-kB binding activity in ES-treated Renca-EGP cells. Furthermore, a supershift assay showed a clear shift of the NF-кB DNA band in samples incubated with a p50 antibody. By immunohistochemistry analysis, ES treatment resulted in a significant reduction in expression of p50. (ES vs. control P<0.05). The immunoprecipitation experiments confirmed the presence of a p50/Bcl-3 complex in nuclear extracts from cells of metastatic lung tissues. Our findings indicate that p50 and Bcl-3 plays a regulatory role in gene transcription in RCC."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biopha.2014.07.008"xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/author | "Scavone C."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/author | "Bellini M.H."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/author | "Foguer K."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/author | "Barbosa Chaves K.C."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/author | "da Silva Paiva K.B."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/author | "de Sa Lima L."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/author | "de Souza Braga M."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/name | "Biomed Pharmacother"xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/pages | "873-879"xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/title | "Involvement of the NF-кB/p50/Bcl-3 complex in response to antiangiogenic therapy in a mouse model of metastatic renal cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/25113400 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25113400 |
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| http://purl.uniprot.org/uniprot/Q61723 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25113400 |
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