| http://purl.uniprot.org/citations/25119050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25119050 | http://www.w3.org/2000/01/rdf-schema#comment | "The balance between stem cell self-renewal and differentiation is controlled by intrinsic factors and niche signals. In the Drosophila melanogaster ovary, some intrinsic factors promote germline stem cell (GSC) self-renewal, whereas others stimulate differentiation. However, it remains poorly understood how the balance between self-renewal and differentiation is controlled. Here we use D. melanogaster ovarian GSCs to demonstrate that the differentiation factor Bam controls the functional switch of the COP9 complex from self-renewal to differentiation via protein competition. The COP9 complex is composed of eight Csn subunits, Csn1-8, and removes Nedd8 modifications from target proteins. Genetic results indicated that the COP9 complex is required intrinsically for GSC self-renewal, whereas other Csn proteins, with the exception of Csn4, were also required for GSC progeny differentiation. Bam-mediated Csn4 sequestration from the COP9 complex via protein competition inactivated the self-renewing function of COP9 and allowed other Csn proteins to promote GSC differentiation. Therefore, this study reveals a protein-competition-based mechanism for controlling the balance between stem cell self-renewal and differentiation. Because numerous self-renewal factors are ubiquitously expressed throughout the stem cell lineage in various systems, protein competition may function as an important mechanism for controlling the self-renewal-to-differentiation switch."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature13562"xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Lu T."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Ni J."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Pan L."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Xie T."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Chamovitz D.A."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Park J.K."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Weng C."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "Yang Z.H."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/author | "McKearin D.M."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/pages | "233-236"xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/title | "Protein competition switches the function of COP9 from self-renewal to differentiation."xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://purl.uniprot.org/core/volume | "514"xsd:string |
| http://purl.uniprot.org/citations/25119050 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25119050 |
| http://purl.uniprot.org/citations/25119050 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25119050 |
| http://purl.uniprot.org/uniprot/Q9VVU5#attribution-51A809311E4008FD0FC6F5EFAE76B1C3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25119050 |