| http://purl.uniprot.org/citations/25120755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25120755 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse aldo-keto reductase family 1 member B8 (AKR1B8) has the highest similarity to human aldo-keto reductase family 1 member B10 (AKR1B10), a secretory protein through lysosomes-mediated non-classical secretory pathway. To identify whether AKR1B8 is secreted through the same pathway, we carried out this study. Self-developed sandwich ELISA and western blot were used to detect AKR1B8 in cells and culture medium of CT-26 murine colon carcinoma cells. AKR1B8 releases in an independent manner to Brefeldin A, an inhibitor of ER-to-Golgi classical secretion pathway. Several factors, which are involved in the non-classical secretion pathway, such as temperature, ATP and calcium ion, regulated AKR1B8 secretion from mouse colorectal cancer cells CT-26. Lysosomotropic NH4Cl increased AKR1B8 secretion, and AKR1B8 was located in isolated lysosomes. Therefore, AKR1B8 is a new secretory protein through the lysosomes-mediated non-classical pathway."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Huang R."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Duan L."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Wang W.C."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Luo W."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Xia C."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Cao D."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/author | "Luo D.X."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/name | "Int J Clin Exp Pathol"xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/pages | "3791-3799"xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/title | "Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway."xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/25120755 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25120755 |
| http://purl.uniprot.org/citations/25120755 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25120755 |
| http://purl.uniprot.org/uniprot/#_P45377-mappedCitation-25120755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25120755 |
| http://purl.uniprot.org/uniprot/P45377 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25120755 |