| http://purl.uniprot.org/citations/25122048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25122048 | http://www.w3.org/2000/01/rdf-schema#comment | "The physiological and pathophysiological significance of collecting duct (CD)-derived renin, particularly as it relates to blood pressure (BP) regulation, is unknown. To address this question, we generated CD-specific renin knockout (KO) mice and examined BP and renal salt and water excretion. Mice containing loxP-flanked exon 1 of the renin gene were crossed with mice transgenic for aquaporin-2-Cre recombinase to achieve CD-specific renin KO. Compared with controls, CD renin KO mice had 70% lower medullary renin mRNA and 90% lower renin mRNA in microdissected cortical CD. Urinary renin levels were significantly lower in KO mice (45% of control levels) while plasma renin concentration was significantly higher in KO mice (63% higher than controls) during normal-Na intake. While no observable differences were noted in BP between the two groups with varying Na intake, infusion of angiotensin II at 400 ng·kg(-1)·min(-1) resulted in an attenuated hypertensive response in the KO mice (mean arterial pressure 111 ± 4 mmHg in KO vs. 128 ± 3 mmHg in controls). Urinary renin excretion and epithelial Na(+) channel (ENaC) remained significantly lower in the KO mice following ANG II infusion compared with controls. Furthermore, membrane-associated ENaC protein levels were significantly lower in KO mice following ANG II infusion. These findings suggest that CD renin modulates BP in ANG II-infused hypertension and these effects are associated with changes in ENaC expression."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00367.2014"xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/author | "Rees S."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/author | "Stuart D."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/author | "Kohan D.E."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/author | "Ramkumar N."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/author | "Sigmund C.D."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/author | "Hoek A.V."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/pages | "F931-8"xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/title | "Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension."xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://purl.uniprot.org/core/volume | "307"xsd:string |
| http://purl.uniprot.org/citations/25122048 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25122048 |
| http://purl.uniprot.org/citations/25122048 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25122048 |
| http://purl.uniprot.org/uniprot/#_P06281-mappedCitation-25122048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122048 |
| http://purl.uniprot.org/uniprot/#_Q9R259-mappedCitation-25122048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122048 |
| http://purl.uniprot.org/uniprot/Q9R259 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25122048 |
| http://purl.uniprot.org/uniprot/P06281 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25122048 |