| http://purl.uniprot.org/citations/25122754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25122754 | http://www.w3.org/2000/01/rdf-schema#comment | "The 5'-3' resection of DNA ends is a prerequisite for the repair of DNA double strand breaks by homologous recombination, microhomology-mediated end joining, and single strand annealing. Recent studies in yeast have shown that, following initial DNA end processing by the Mre11-Rad50-Xrs2 complex and Sae2, the extension of resection tracts is mediated either by exonuclease 1 or by combined activities of the RecQ family DNA helicase Sgs1 and the helicase/endonuclease Dna2. Although human DNA2 has been shown to cooperate with the BLM helicase to catalyze the resection of DNA ends, it remains a matter of debate whether another human RecQ helicase, WRN, can substitute for BLM in DNA2-catalyzed resection. Here we present evidence that WRN and BLM act epistatically with DNA2 to promote the long-range resection of double strand break ends in human cells. Our biochemical experiments show that WRN and DNA2 interact physically and coordinate their enzymatic activities to mediate 5'-3' DNA end resection in a reaction dependent on RPA. In addition, we present in vitro and in vivo data suggesting that BLM promotes DNA end resection as part of the BLM-TOPOIIIα-RMI1-RMI2 complex. Our study provides new mechanistic insights into the process of DNA end resection in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.578823"xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/author | "Cejka P."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/author | "Janscak P."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/author | "Pinto C."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/author | "Sturzenegger A."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/author | "Kanagaraj R."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/author | "Burdova K."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/author | "Levikova M."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/pages | "27314-27326"xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/title | "DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells."xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/25122754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25122754 |
| http://purl.uniprot.org/citations/25122754 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25122754 |
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| http://purl.uniprot.org/uniprot/#_Q14191-mappedCitation-25122754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122754 |
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| http://purl.uniprot.org/uniprot/#_B7Z8C1-mappedCitation-25122754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122754 |
| http://purl.uniprot.org/uniprot/#_B7ZKN7-mappedCitation-25122754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122754 |
| http://purl.uniprot.org/uniprot/#_B7Z2X2-mappedCitation-25122754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122754 |
| http://purl.uniprot.org/uniprot/#_P49959-mappedCitation-25122754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122754 |
| http://purl.uniprot.org/uniprot/#_Q13472-mappedCitation-25122754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25122754 |