| http://purl.uniprot.org/citations/25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25128388 | http://www.w3.org/2000/01/rdf-schema#comment | "Maintenance of the correct reading frame on the ribosome is essential for accurate protein synthesis. Here, we report structures of the 70S ribosome bound to frameshift suppressor tRNA(SufA6) and N1-methylguanosine at position 37 (m(1)G37) modification-deficient anticodon stem loop(Pro), both of which cause the ribosome to decode 4 rather than 3 nucleotides, resulting in a +1 reading frame. Our results reveal that decoding at +1 suppressible codons causes suppressor tRNA(SufA6) to undergo a rearrangement of its 5' stem that destabilizes U32, thereby disrupting the conserved U32-A38 base pair. Unexpectedly, the removal of the m(1)G37 modification of tRNA(Pro) also disrupts U32-A38 pairing in a structurally analogous manner. The lack of U32-A38 pairing provides a structural correlation between the transition from canonical translation and a +1 reading of the mRNA. Our structures clarify the molecular mechanism behind suppressor tRNA-induced +1 frameshifting and advance our understanding of the role played by the ribosome in maintaining the correct translational reading frame."xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1409436111"xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/author | "Dunham C.M."xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/author | "Maehigashi T."xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/author | "Miles S.J."xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/author | "Dunkle J.A."xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/pages | "12740-12745"xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/title | "Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops."xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/25128388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25128388 |
| http://purl.uniprot.org/citations/25128388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25128388 |
| http://purl.uniprot.org/uniprot/#_P35871-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P0DOY6-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P0DOY7-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P0DOY8-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P0DOY9-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P17291-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P80256-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P80339-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
| http://purl.uniprot.org/uniprot/#_P80340-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |
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| http://purl.uniprot.org/uniprot/#_P80372-mappedCitation-25128388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25128388 |