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| http://purl.uniprot.org/citations/25129435 | http://www.w3.org/2000/01/rdf-schema#comment | "We used the LEW1.WR1 rat model of Kilham Rat Virus (KRV)-induced type 1 diabetes (T1D) to test the hypothesis that disease mechanisms are linked with beta cell infection and intra-islet immune activation prior to insulitis. KRV induces genes involved in type I and type II interferon pathways in islet cell lines in vitro and in islets from day-5-infected animals in vivo via mechanisms that do not involve insulitis, beta cell apoptosis, or impaired insulin expression. Immunohistochemistry studies indicated that KRV protein is expressed in beta cells 5 days following infection. KRV induces the phosphorylation of Janus Kinase 1/2 (JAK1/2) and signal transducer and activator of transcription 1 (STAT-1) in islet cells via a mechanism that could involve TLR9 and NF-κB pathways. These data demonstrate for the first time that KRV-induced islet destruction is associated with beta cell infection and intra-islet innate immune upregulation early in the disease process."xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.07.041"xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/author | "Hara N."xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/author | "Zipris D."xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/author | "Gianani R."xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/author | "Alkanani A.K."xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/pages | "19-27"xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/title | "Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis."xsd:string |
| http://purl.uniprot.org/citations/25129435 | http://purl.uniprot.org/core/volume | "468-470"xsd:string |
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