| http://purl.uniprot.org/citations/25130147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25130147 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. It is a clinically heterogeneous disorder especially in terms of disease severity. Current investigations suggest that genes and gene-gene interactions not only influence on susceptibility to MS but also affect the disease severity. In this study, we investigated the contribution of the HLADRB1*1501 allele and single nucleotide polymorphism (SNP) in CD24 gene and also combined genotypes of the HLADRB1*1501 and CD24 SNP to disease severity in Iranian MS patients. We have reported previously that the HLA-DRB1*1501 allele and the CD24v/v genotype associated with disease susceptibility and some other studies proposed that HLA-DRB1*1501 allele be associated with MS severity. In this study, the results showed a significant difference in the Multiple Sclerosis Severity Score (MSSS) of the nine different genotypes (F=2.838, P=0.007). Subsequent analysis revealed a statistically significant difference in the MSSS between the MS patients who were carriers of HLA-DRB1*1501/1501 and those who were not carriers of HLA-DRB1*1501/1501 genotypes (P=0.04). Moreover, the MS patients carrying combined genotypes of the HLA-DRB1*1501/x-CD24 v/v had statistically severe disease than the patients who did not carry the HLA- DRB1*1501-CD24 v/v (P=0.047). In conclusion, our findings suggest that, HLA-DRB1*1501/1501 and bigenic genotypes of the HLA- DRB1*1501/x-CD24 v/v may influence on disease severity in Iranian MS patients."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/author | "Zamani M."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/author | "Kollaee A."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/author | "Ghlichnia H.A."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/author | "Movafagh A."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/author | "Gaffarpoor M."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/author | "Ghlichnia B."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/name | "Acta Med Iran"xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/pages | "418-423"xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/title | "The influence of combined genotypes of the HLADRB1*1501 and CD24 single nucleotide polymorphism on disease severity of Iranian multiple sclerosis patients."xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/25130147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25130147 |
| http://purl.uniprot.org/citations/25130147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25130147 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-25130147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25130147 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-25130147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25130147 |
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| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-25130147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25130147 |
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| http://purl.uniprot.org/uniprot/#_A0A0A0WB88-mappedCitation-25130147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25130147 |