| http://purl.uniprot.org/citations/25135296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25135296 | http://www.w3.org/2000/01/rdf-schema#comment | "The focus of this study is the characterization of human T cell blood-brain barrier migration and corresponding molecular trafficking signatures. We examined peripheral blood and cerebrospinal fluid immune cells from patients under long-term anti-very late antigen-4 (VLA-4)/natalizumab therapy (LTNT) and from CNS specimens. LTNT patients' cerebrospinal fluid T cells exhibited healthy central-/effector-memory ratios, but lacked CD49d and showed enhanced myeloma cell adhesion molecule (MCAM) expression. LTNT led to an increase of PSGL-1 expression on peripheral T cells. Although vascular cell adhesion molecule-1 (VLA-4 receptor) was expressed at all CNS barriers, P-selectin (PSGL-1-receptor) was mainly detected at the choroid plexus. Accordingly, in vitro experiments under physiological flow conditions using primary human endothelial cells and LTNT patients' T cells showed increased PSGL-1-mediated rolling and residual adhesion, even under VLA-4 blockade. Adhesion of MCAM(+)/TH17 cells was not affected by VLA-4 blocking alone, but was abrogated when both VLA-4 and MCAM were inhibited. Consistent with these data, MCAM(+) cells were detected in white matter lesions, and in gray matter of multiple sclerosis patients. Our data indicate that lymphocyte trafficking into the CNS under VLA-4 blockade can occur by using the alternative adhesion molecules, PSGL-1 and MCAM, the latter representing an exclusive pathway for TH17 cells to migrate over the blood-brain barrier."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20140540"xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Breuer J."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Vestweber D."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Kuhlmann T."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Sorokin L."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Zarbock A."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Wiendl H."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Mohan H."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Flanagan K."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Schwab N."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Gross C.C."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Boning D."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Schneider-Hohendorf T."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/author | "Rossaint J."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/pages | "1833-1846"xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/title | "VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells."xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://purl.uniprot.org/core/volume | "211"xsd:string |
| http://purl.uniprot.org/citations/25135296 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25135296 |
| http://purl.uniprot.org/citations/25135296 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25135296 |
| http://purl.uniprot.org/uniprot/#_A0A023IP86-mappedCitation-25135296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25135296 |
| http://purl.uniprot.org/uniprot/#_Q14242-mappedCitation-25135296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25135296 |