| http://purl.uniprot.org/citations/25138159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25138159 | http://www.w3.org/2000/01/rdf-schema#comment | "Serine proteases, serine protease inhibitors, and protease-activated receptors (PARs) are responsible for several human skin disorders characterized by impaired epidermal permeability barrier function, desquamation, and inflammation. In this study, we addressed the consequences of a catalytically dead serine protease on epidermal homeostasis, the activation of PAR2 and the inhibition by the serine protease inhibitor nexin-1. The catalytically inactive serine protease CAP1/Prss8, when ectopically expressed in the mouse, retained the ability to induce skin disorders as well as its catalytically active counterpart (75%, n=81). Moreover, this phenotype was completely normalized in a PAR2-null background, indicating that the effects mediated by the catalytically inactive CAP1/Prss8 depend on PAR2 (95%, n=131). Finally, nexin-1 displayed analogous inhibitory capacity on both wild-type and inactive mutant CAP1/Prss8 in vitro and in vivo (64% n=151 vs. 89% n=109, respectively), indicating that the catalytic site of CAP1/Prss8 is dispensable for nexin-1 inhibition. Our results demonstrate a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.14-253781"xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Zoete V."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Iwaszkiewicz J."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Sergi C."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Hummler E."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Merillat A.M."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Crisante G."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Frateschi S."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Nesca V."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/author | "Battista L."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/pages | "4792-4805"xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/title | "The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition."xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/25138159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25138159 |
| http://purl.uniprot.org/citations/25138159 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25138159 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ70-mappedCitation-25138159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25138159 |
| http://purl.uniprot.org/uniprot/#_A0A087WQM1-mappedCitation-25138159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25138159 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RQA6-mappedCitation-25138159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25138159 |
| http://purl.uniprot.org/uniprot/#_B1ARS0-mappedCitation-25138159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25138159 |
| http://purl.uniprot.org/uniprot/#_P40124-mappedCitation-25138159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25138159 |
| http://purl.uniprot.org/uniprot/#_Q3U0U5-mappedCitation-25138159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25138159 |