| http://purl.uniprot.org/citations/25148024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25148024 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8αα(+) intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial barrier in the intestine. Similar to natural killer cells and other innate lymphoid cells, CD8αα(+) IELs constitutively express the T-box transcription factor T-bet. However, the precise role of T-bet for the differentiation or function of IELs is unknown. Here we show that mice genetically deficient for T-bet lacked both TCRαβ(+) and TCRγδ(+) CD8αα(+) IELs and thus are more susceptible to chemically induced colitis. Although T-bet was induced in thymic IEL precursors (IELPs) as a result of agonist selection and interleukin-15 (IL-15) receptor signaling, it was dispensable for the generation of IELPs. Subsequently, T-bet was required for the IL-15-dependent activation, differentiation, and expansion of IELPs in the periphery. Our study reveals a function of T-bet as a central transcriptional regulator linking agonist selection and IL-15 signaling with the emergence of CD8αα(+) IELs."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2014.06.018"xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Ebert K."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Palmer E."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Diefenbach A."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Arnold S.J."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Hernandez P.P."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Tanriver Y."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Klose C.S."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "d'Hargues Y."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Blatz K."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Kofoed-Nielsen M."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/author | "Ripka J.F."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/pages | "230-243"xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/title | "The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8alphaalpha(+) intraepithelial lymphocyte development."xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/25148024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25148024 |
| http://purl.uniprot.org/citations/25148024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25148024 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1L1-mappedCitation-25148024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25148024 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-25148024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25148024 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ8-mappedCitation-25148024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25148024 |
| http://purl.uniprot.org/uniprot/#_F6VSW9-mappedCitation-25148024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25148024 |