| http://purl.uniprot.org/citations/25148025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25148025 | http://www.w3.org/2000/01/rdf-schema#comment | "The intestinal epithelium harbors large populations of activated and memory lymphocytes, yet these cells do not cause tissue damage in the steady state. We investigated how intestinal T cell effector differentiation is regulated upon migration to the intestinal epithelium. Using gene loss- and gain-of-function strategies, as well as reporter approaches, we showed that cooperation between the transcription factors T-bet and Runx3 resulted in suppression of conventional CD4(+) T helper functions and induction of an intraepithelial lymphocyte (IEL) program that included expression of IEL markers such as CD8αα homodimers. Interferon-γ sensing and T-bet expression by CD4(+) T cells were both required for this program, which was distinct from conventional T helper differentiation but shared by other IEL populations, including TCRαβ(+)CD8αα(+) IELs. We conclude that the gut environment provides cues for IEL maturation through the interplay between T-bet and Runx3, allowing tissue-specific adaptation of mature T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2014.06.017"xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/author | "Grivennikov S.I."xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/author | "Mucida D."xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/author | "Reis B.S."xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/author | "Hoytema van Konijnenburg D.P."xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/pages | "244-256"xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/title | "Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation."xsd:string |
| http://purl.uniprot.org/citations/25148025 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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