| http://purl.uniprot.org/citations/25149452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25149452 | http://www.w3.org/2000/01/rdf-schema#comment | "The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.04177"xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Chiba S."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Kimura Y."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Tamura T."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Saijo S."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Nishio J."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Yanai H."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Ikushima H."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Hangai S."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Negishi H."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/author | "Ueki H."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/pages | "e04177"xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/title | "Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses."xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/25149452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25149452 |
| http://purl.uniprot.org/citations/25149452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25149452 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY5-mappedCitation-25149452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25149452 |
| http://purl.uniprot.org/uniprot/#_E9Q5T2-mappedCitation-25149452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25149452 |
| http://purl.uniprot.org/uniprot/#_P56477-mappedCitation-25149452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25149452 |