| http://purl.uniprot.org/citations/25150005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25150005 | http://www.w3.org/2000/01/rdf-schema#comment | "Motor nerve injury by L5 ventral root transection (L5-VRT) initiates interleukin-6 (IL-6) up-regulation in primary afferent system contributing to neuropathic pain. However, the early upstream regulatory mechanisms of IL-6 after L5-VRT are still unknown. Here, we monitored both the activity of calpain, a calcium-dependent protease suggested as one of the earliest mediators for cytokine regulation, and the expression of IL-6 in bilateral L4-L6 dorsal root ganglias (DRGs) soon after L5-VRT. We found that the protein level of calpain-2 in DRGs, but not calpain-1 was increased transiently in the first 10 min(-1)h ipsilaterally and 20 min(-1)h contralaterally after L5-VRT, long before mechanical allodynia was initiated (5-15 h ipsilaterally and 15 h(-1)d contralaterally). The early activation of calpain evaluated by the generation of spectrin breakdown products (SBDP) correlated well with IL-6 up-regulation in bilateral DRGs. Double immunofluorescence staining revealed that almost all the calpain-2 positive neurons expressed IL-6, indicating an association between calpain-2 and IL-6. Inhibition of calpain by pre-treatment with MDL28170 (25mg/kg, i.p.) attenuated the rat mechanical allodynia and prevented the early up-regulation of IL-6 following L5-VRT. Addition of exogenous calpain-2 onto the surface of left L5 DRG triggered a temporal allodynia and increased IL-6 in bilateral DRGs simultaneously. Taken together, the early increase of calpain-2 in L5-VRT rats might be responsible for the induction of allodynia via up-regulating IL-6 in DRG neurons."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbi.2014.08.003"xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Zhu H.Q."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Cui Y."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Chen S.X."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Zang Y."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Zhou L.J."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Liu X.G."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Wei X.H."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Xin W.J."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Pang R.P."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Liao G.J."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/author | "Na X.D."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/name | "Brain Behav Immun"xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/pages | "37-47"xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/title | "Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons."xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/25150005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25150005 |
| http://purl.uniprot.org/citations/25150005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25150005 |
| http://purl.uniprot.org/uniprot/Q07009#attribution-351ADA02BECA1089FB40136E69BC2512 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25150005 |
| http://purl.uniprot.org/uniprot/Q07009#attribution-4DC8E0855A7C6238409BAE4507844E00 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25150005 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A3B4-mappedCitation-25150005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25150005 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y510-mappedCitation-25150005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25150005 |