| http://purl.uniprot.org/citations/25151500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25151500 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphocyte antigen-4 (CTLA-4), glucocorticoid-induced TNFR family-related gene (GITR), Helios and neuropilin-1 (NRP-1) as well as forkhead box protein 3 (FOXP3) were specifically expressed by these CD83(+) T cells. In contrast, CD83(-) T cells showed a naive T cell phenotype with effector T cell properties upon activation. Noteworthy, CD83(-) T cells were not able to upregulate CD83 despite activation. Furthermore, CD83(+) T cells suppressed the proliferation and inflammatory cytokine release of CD83(-) T cells in vitro. Strikingly, stimulated CD83(+) T cells released soluble CD83 (sCD83), which has been reported to possess immunosuppressive properties. In vivo, using the murine transfer colitis model we could show that CD83(+) T cells were able to suppress colitis symptoms while CD83(-) T cells possessed effector functions. In addition, this CD83 expression is also conserved on expanded human Treg. Thus, from these studies we conclude that CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imbio.2014.08.005"xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Stein M."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Seitz C."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Becker C."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Steinkasserer A."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Gunther C."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Kuhnt C."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Lechmann M."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Eckhardt J."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Knippertz I."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Kreiser S."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Krzyzak L."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/author | "Tucher C."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/name | "Immunobiology"xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/pages | "270-279"xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/title | "Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://purl.uniprot.org/core/volume | "220"xsd:string |
| http://purl.uniprot.org/citations/25151500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25151500 |
| http://purl.uniprot.org/citations/25151500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25151500 |
| http://purl.uniprot.org/uniprot/#_A0A087WX61-mappedCitation-25151500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25151500 |
| http://purl.uniprot.org/uniprot/#_O88324-mappedCitation-25151500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25151500 |
| http://purl.uniprot.org/uniprot/#_Q01151-mappedCitation-25151500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25151500 |