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| http://purl.uniprot.org/citations/25152040 | http://www.w3.org/2000/01/rdf-schema#comment | "A common post-transcriptional modification of RNA is the conversion of uridine to its isomer pseudouridine. We investigated the biological significance of eukaryotic pseudouridine synthases using the yeast Saccharomyces cerevisiae. We conducted a comprehensive statistical analysis on growth data from automated perturbation (gene deletion) experiments, and used bi-logistic curve analysis to characterise the yeast phenotypes. The deletant strains displayed different alteration in growth properties, including in some cases enhanced growth and/or biphasic growth curves not seen in wild-type strains under matched conditions. These results demonstrate that disrupting pseudouridine synthases can have a significant qualitative effect on growth. We further investigated the significance of post-transcriptional pseudouridine modification through investigation of the scientific literature. We found that (1) In Toxoplasma gondii, a pseudouridine synthase gene is critical in cellular differentiation between the two asexual forms: Tachyzoites and bradyzoites; (2) Mutation of pseudouridine synthase genes has also been implicated in human diseases (mitochondrial myopathy and sideroblastic anemia (MLASA); dyskeratosis congenita). Taken together, these results are consistent with pseudouridine synthases having a Gene Ontology function of "biological regulation"."xsd:string |
| http://purl.uniprot.org/citations/25152040 | http://purl.org/dc/terms/identifier | "doi:10.1142/s0219720014500152"xsd:string |
| http://purl.uniprot.org/citations/25152040 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/25152040 | http://purl.uniprot.org/core/author | "King R.D."xsd:string |
| http://purl.uniprot.org/citations/25152040 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25152040 | http://purl.uniprot.org/core/name | "J Bioinform Comput Biol"xsd:string |
| http://purl.uniprot.org/citations/25152040 | http://purl.uniprot.org/core/pages | "1450015"xsd:string |
| http://purl.uniprot.org/citations/25152040 | http://purl.uniprot.org/core/title | "An investigation into eukaryotic pseudouridine synthases."xsd:string |
| http://purl.uniprot.org/citations/25152040 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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