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http://purl.uniprot.org/citations/25153995http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25153995http://www.w3.org/2000/01/rdf-schema#comment"

Background

Matrix metalloproteinase (MMP)-9 may play a central role in the development and progression of atherosclerosis. Emerging evidence also indicates an association between MMP-9 and depressive symptomatology. Here, we investigated whether expression of MMP-9 and its inhibitors in blood mononuclear cells and plasma were related to depressive symptoms in patients with a recent myocardial infarction (MI).

Methods and results

Blood sampling was performed between 6 and 18 months after MI in 57 patients. Forty-one clinically healthy subjects were included as controls. Gene expression of MMP-9 and its main tissue inhibitors TIMP-1 and -2 were analyzed in freshly isolated or cultured blood mononuclear cells. Corresponding protein levels were assessed in cell supernatants and plasma. In post-MI patients, mRNA levels of MMP-9 and TIMP-1 and -2 were significantly higher than in controls while protein levels in cell supernatants and plasma did not differ between groups. The Center for Epidemiological Studies - Depression (CES-D) scale was used to assess depressive symptomatology. Repeated assessments during the first 18 months after MI showed significantly higher CES-D scores in patients compared with controls. However, there were no relationships between depressive mood and any of the measurements of MMP-9 or TIMPs.

Conclusion

Our findings indicate that overexpression of MMP-9 and TIMPs in blood mononuclear cells and elevated depressive symptoms represent two unrelated phenomena after MI."xsd:string
http://purl.uniprot.org/citations/25153995http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0105572"xsd:string
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/author"Jonsson S."xsd:string
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/author"Jonasson L."xsd:string
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/author"Lundberg A.K."xsd:string
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/pages"e105572"xsd:string
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/title"Overexpression of MMP-9 and its inhibitors in blood mononuclear cells after myocardial infarction--is it associated with depressive symptomatology?"xsd:string
http://purl.uniprot.org/citations/25153995http://purl.uniprot.org/core/volume"9"xsd:string
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