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http://purl.uniprot.org/citations/25154675http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25154675http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate whether specific genetic polymorphisms in the cyclin-dependent kinase inhibitor 2B antisense RNA (CDKN2B-AS) gene and near the wingless-type MMTV integration site family member 4 (WNT4) gene are associated with endometriosis in a Korean population.

Design

Case-control genetic association study.

Setting

University.

Patient(s)

Surgically or histologically diagnosed cases of endometriosis (n=673) and controls (n=500) among a population of ethnic Koreans.

Intervention(s)

None.

Main outcome measure(s)

Genotype distribution and synergistic interaction.

Result(s)

Significant differences were found in the allele distributions of the CC genotype of the rs10965235 single-nucleotide polymorphism (SNP) of the CDKN2B-AS gene and the GG genotype of the rs16826658 SNP on chromosome 1p36 between the endometriosis cases and the controls (rs10965235: 69.7% CC, 26.9% CA, and 3.4% AA vs. 59.2% CC, 35.2% CA, and 5.6% AA; rs16826658: 33.7% GG, 48.4% GT, and 17.8% TT vs. 25.6% GG, 49.8% GT, and 24.6% TT, respectively). A significant interaction was not found between the CC genotype of the rs10965235 SNP and the GG genotype of the rs16826658 SNP after Bonferroni correction (32.8% of CC+GG and 67.2% of CC+non-GG in the endometriosis cases vs. 25.0% of CC+GG and 75.0% of CC+non-GG in the controls).

Conclusion(s)

Our results suggest that the rs10965235 SNP in the CDKN2B-AS gene and the rs16826658 SNP near the WNT4 gene were significantly associated with endometriosis in this Korean population."xsd:string
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http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/author"Kim J.J."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/author"Yoon S.H."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/author"Lee G.H."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/author"Hwang K."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/author"Choi Y.M."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/author"Hong M.A."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/author"Chae S.J."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/name"Fertil Steril"xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/pages"1393-1397"xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/title"Association of CDKN2B-AS and WNT4 genetic polymorphisms in Korean patients with endometriosis."xsd:string
http://purl.uniprot.org/citations/25154675http://purl.uniprot.org/core/volume"102"xsd:string
http://purl.uniprot.org/citations/25154675http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25154675
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