| http://purl.uniprot.org/citations/25155755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25155755 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous oncogenic mutations occur within the BRAF kinase domain (BRAF(KD)). Here we show that stable BRAF-MEK1 complexes are enriched in BRAF(WT) and KRAS mutant (MT) cells but not in BRAF(MT) cells. The crystal structure of the BRAF(KD) in a complex with MEK1 reveals a face-to-face dimer sensitive to MEK1 phosphorylation but insensitive to BRAF dimerization. Structure-guided studies reveal that oncogenic BRAF mutations function by bypassing the requirement for BRAF dimerization for activity or weakening the interaction with MEK1. Finally, we show that conformation-specific BRAF inhibitors can sequester a dormant BRAF-MEK1 complex resulting in pathway inhibition. Taken together, these findings reveal a regulatory role for BRAF in the MAPK pathway independent of its kinase activity but dependent on interaction with MEK."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2014.07.007"xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Smith D."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Sandoval W."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Brandhuber B.J."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Giannetti A.M."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Peck A."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Hymowitz S.G."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Malek S."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Sudhamsu J."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Morales T."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Sideris S."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Haling J.R."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Yen I."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Bravo B.J."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Masselot A."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/author | "Phung W."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/pages | "402-413"xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/title | "Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling."xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/25155755 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25155755 |
| http://purl.uniprot.org/citations/25155755 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25155755 |