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http://purl.uniprot.org/citations/25156852http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25156852http://www.w3.org/2000/01/rdf-schema#comment"

Background

Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signaling, would lead to aggravated cardiac dysfunction after MI.

Methods and results

First, whole blood from RP105-/- and wild-type (WT) male C57Bl/6N mice was stimulated with LPS, which induced a strong inflammatory TNFα response in RP105-/-mice. Then, baseline heart function was assessed by left ventricular pressure-volume relationships which were not different between RP105-/- and WT mice. Permanent ligation of the left anterior descending coronary artery was performed to induce MI. Infarct sizes were analyzed by (immuno)histology and did not differ. Fifteen days post MI heart function was assessed and RP105-/-mice had significantly higher heart rate (+21%, P<0.01), end systolic volume index (+57%, P<0.05), end systolic pressure (+22%, P<0.05) and lower relaxation time constant tau (-12%, P<0.05), and a tendency for increased end diastolic volume index (+42%, P<0.06), compared to WT mice. In the area adjacent to the infarct zone, compared to the healthy myocardium, levels of RP105, TLR4 and the endogenous TLR4 ligand fibronectin-EDA were increased as well as the number of macrophages, however this was not different between both groups.

Conclusion

Deficiency of the endogenous TLR4 inhibitor RP105 leads to an enhanced inflammatory status and more pronounced cardiac dilatation after induction of MI, underscoring the role of the TLR4 pathway in post-infarction remodeling."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.org/dc/terms/identifier"doi:10.1016/j.ijcard.2014.07.086"xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Smit J.W."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Rensen P.C."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"de Vries M.R."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Quax P.H."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Steendijk P."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Willems van Dijk K."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Nossent A.Y."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"van der Hoorn J.W."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Karper J.C."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Bastiaansen A.J."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/author"Louwe M.C."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/name"Int J Cardiol"xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/pages"788-793"xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/title"RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice."xsd:string
http://purl.uniprot.org/citations/25156852http://purl.uniprot.org/core/volume"176"xsd:string
http://purl.uniprot.org/citations/25156852http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25156852
http://purl.uniprot.org/citations/25156852http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25156852
http://purl.uniprot.org/uniprot/#_Q3U0U7-mappedCitation-25156852http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25156852
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http://purl.uniprot.org/uniprot/Q62192http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25156852
http://purl.uniprot.org/uniprot/Q3U0U7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25156852
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