| http://purl.uniprot.org/citations/25157096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25157096 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 1 diabetes (T1D) develops when insulin-secreting β-cells, found in the pancreatic islets of Langerhans, are destroyed by infiltrating T cells. How human T cells recognize β-cell-derived antigens remains unclear. Genetic studies have shown that HLA and insulin alleles are the most strongly associated with risk of T1D. These long-standing observations implicate CD4(+) T-cell responses against (pro)insulin in the pathogenesis of T1D. To dissect the autoimmune T-cell response against human β-cells, we isolated and characterized 53 CD4(+) T-cell clones from within the residual pancreatic islets of a deceased organ donor who had T1D. These 53 clones expressed 47 unique clonotypes, 8 of which encoded proinsulin-specific T-cell receptors. On an individual clone basis, 14 of 53 CD4(+) T-cell clones (26%) recognized 6 distinct but overlapping epitopes in the C-peptide of proinsulin. These clones recognized C-peptide epitopes presented by HLA-DQ8 and, notably, HLA-DQ8 transdimers that form in HLA-DQ2/-DQ8 heterozygous individuals. Responses to these epitopes were detected in the peripheral blood mononuclear cells of some people with recent-onset T1D but not in HLA-matched control subjects. Hence, proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4(+) T cells are strongly implicated in the autoimmune pathogenesis of human T1D."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.org/dc/terms/identifier | "doi:10.2337/db14-0858"xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Thomas H.E."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Hill E."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Brodnicki T.C."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "O'Connell P.J."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Krishnamurthy B."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Bergman P."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Dudek N.L."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Mannering S.I."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Campbell P.D."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Coates P.T."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Kedzierska K."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Loudovaris T."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Kay T.W."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Rodda C."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Kuehlich J.P."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/author | "Pathiraja V."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/pages | "172-182"xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/title | "Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/25157096 | http://purl.uniprot.org/core/volume | "64"xsd:string |