| http://purl.uniprot.org/citations/25157163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25157163 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein ubiquitination is a core regulatory determinant of neural development. Previous studies have indicated that the Nedd4-family E3 ubiquitin ligases Nedd4-1 and Nedd4-2 may ubiquitinate phosphatase and tensin homolog (PTEN) and thereby regulate axonal growth in neurons. Using conditional knockout mice, we show here that Nedd4-1 and Nedd4-2 are indeed required for axonal growth in murine central nervous system neurons. However, in contrast to previously published data, we demonstrate that PTEN is not a substrate of Nedd4-1 and Nedd4-2, and that aberrant PTEN ubiquitination is not involved in the impaired axon growth upon deletion of Nedd4-1 and Nedd4-2. Rather, PTEN limits Nedd4-1 protein levels by modulating the activity of mTORC1, a protein complex that controls protein synthesis and cell growth. Our data demonstrate that Nedd4-family E3 ligases promote axonal growth and branching in the developing mammalian brain, where PTEN is not a relevant substrate. Instead, PTEN controls neurite growth by regulating Nedd4-1 expression."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1400737111"xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Eickholt B.J."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Takeda M."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Rotin D."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Nakashima J."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "An W."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Brose N."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Rhee J.S."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Rossner M.J."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Polleux F."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Bagni C."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Kawabe H."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Goebbels S."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Courchet J."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Hsia H.E."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/author | "Luca R."xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/pages | "13205-13210"xsd:string |
| http://purl.uniprot.org/citations/25157163 | http://purl.uniprot.org/core/title | "Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth."xsd:string |