| http://purl.uniprot.org/citations/25162226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25162226 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of peroxiredoxin 1 (Prx1) has been observed in numerous cancers including oral squamous cell carcinoma (OSCC). The precise molecular mechanism of up-regulation of Prx1 in carcinogenesis, however, is still poorly understood. The objective of this study is to investigate the relationship between Prx1 and hypoxia, and potential mechanism(s) of Prx1 in OSCC cell line SCC15 and xenograft model. We treated wild-type and Prx1 knockdown SCC15 cells with transient hypoxia followed by reoxygenation. We detected the condition of hypoxia, production of reactive oxygen species (ROS), and expression and/or activity of Prx1, heme oxygenase 1 (HO-1) and nuclear factor-kappa B (NF-κB). We found that hypoxia induces ROS accumulation, up-regulates Prx1, increases NF-κB translocation and DNA binding activity, and down-regulates HO-1 in vitro. In Prx1 knockdown cells, the expression level of HO-1 was increased, while NFκB translocation and DNA binding activity were decreased after hypoxia or hypoxia/reoxygenation treatment. Moreover, we mimicked the dynamic oxygenation tumor microenvironment in xenograft model and assessed the above indices in tumors with the maximal diameter of 2 mm, 5 mm, 10 mm or 15 mm, respectively. Our data showed that tumor hypoxic condition and expression of Prx1 are significantly associated with tumor growth. The expression of HO-1 and NF-κB, and NF-κB DNA binding activity were significantly elevated in 15 mm tumors, and the level of 8-hydroxydeoxyguanosine was increased in 10 mm and 15 mm tumors, compared to those in size of 2 mm. The results from this study provide experimental evidence that overexpression of Prx1 is associated with hypoxia, and Prx1/NF-κB/HO-1 signaling pathway may be involved in oral carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0105994"xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Hou M."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Miao C."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Jing X."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Ge L."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/author | "Shi N."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/pages | "e105994"xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/title | "Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-kappaB in oral cancer."xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25162226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25162226 |
| http://purl.uniprot.org/citations/25162226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25162226 |
| http://purl.uniprot.org/uniprot/#_F2YMD9-mappedCitation-25162226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25162226 |
| http://purl.uniprot.org/uniprot/#_D2K7W4-mappedCitation-25162226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25162226 |
| http://purl.uniprot.org/uniprot/#_P63013-mappedCitation-25162226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25162226 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-25162226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25162226 |
| http://purl.uniprot.org/uniprot/#_A0A384NPQ2-mappedCitation-25162226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25162226 |
| http://purl.uniprot.org/uniprot/#_B2R7U4-mappedCitation-25162226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25162226 |