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http://purl.uniprot.org/citations/25165391http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25165391http://www.w3.org/2000/01/rdf-schema#comment"

Background

The kidney-specific sodium-potassium-chloride cotransporter (NKCC2) protein encoded by solute carrier family 12 member 1 (SLC12A1) is the direct downstream effector of the inward-rectifier potassium channel (ROMK) encoded by potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), both of which are critical for calcium reabsorption in the kidney.

Objective

We hypothesized that polymorphisms in KCNJ1, SLC12A1, and 7 other genes may modify the association between calcium intake and colorectal neoplasia risk.

Methods

We conducted a 2-phase study in 1336 cases and 2891 controls from the Tennessee Colorectal Polyp Study.

Results

In phase I, we identified 5 single-nucleotide polymorphisms (SNPs) that significantly interacted with calcium intake in adenoma risk. In phase II, rs2855798 in KCNJ1 was replicated. In combined analysis of phases I and II, the P values for interactions between calcium intake and rs2855798 were 1 × 10(-4) for all adenoma and 5 × 10(-3) for multiple/advanced adenoma. The highest calcium intake was not associated with risk among those with no variant allele but was significantly associated with a 41% reduced adenoma risk among those who carried at least 1 variant allele in KCNJ1. The corresponding reduction in risk of multiple or advanced adenomas was 52% among those with at least 1 variant allele. The P values for interactions between calcium intake and combined SNPs from the KCNJ1 and SLC12A1 genes were 7.5 × 10(-5) for adenoma and 9.9 × 10(-5) for multiple/advanced adenoma. The highest calcium intake was not associated with risk among those with nonvariant alleles in 2 genes but was significantly associated with a 34% reduced adenoma risk among those who carried a variant allele in 1 of the genes. The corresponding reduction in risk of multiple or advanced adenomas was 64% among those with variant alleles in both genes.

Conclusion

These findings, if confirmed, will be critical for the development of personalized prevention strategies for colorectal cancer."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.org/dc/terms/identifier"doi:10.3945/jn.114.196709"xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Chen Z."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Cai Q."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Li G."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Zhu X."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Zheng W."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Zhang B."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Long J."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Dai Q."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Liang J."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Giovannucci E."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Edwards T.L."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Shrubsole M.J."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Ness R.M."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Smalley W.E."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/author"Wiese D."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/name"J Nutr"xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/pages"1734-1741"xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/title"Calcium intake and ion transporter genetic polymorphisms interact in human colorectal neoplasia risk in a 2-phase study."xsd:string
http://purl.uniprot.org/citations/25165391http://purl.uniprot.org/core/volume"144"xsd:string
http://purl.uniprot.org/citations/25165391http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25165391
http://purl.uniprot.org/citations/25165391http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25165391
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