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http://purl.uniprot.org/citations/25170533http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25170533http://www.w3.org/2000/01/rdf-schema#comment"MicroRNAs regulate gene expression in numerous biological pathways and are typically methylated at their 3'-termini in plants but not in animals. Here we show that the HEN1 RNA 2'-O-methyltransferase from Arabidopsis thaliana catalyzes the transfer of extended propargylic moieties from synthetic AdoMet cofactor analogs to duplex miRNAs or siRNAs. The presented approach permits selective and efficient covalent labeling of small RNA duplexes with a variety of functional or reporter groups for their enrichment and analysis."xsd:string
http://purl.uniprot.org/citations/25170533http://purl.org/dc/terms/identifier"doi:10.1021/ja507390s"xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/author"Klimasauskas S."xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/author"Vilkaitis G."xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/author"Plotnikova A."xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/author"Osipenko A."xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/author"Masevicius V."xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/name"J Am Chem Soc"xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/pages"13550-13553"xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/title"Selective covalent labeling of miRNA and siRNA duplexes using HEN1 methyltransferase."xsd:string
http://purl.uniprot.org/citations/25170533http://purl.uniprot.org/core/volume"136"xsd:string
http://purl.uniprot.org/citations/25170533http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25170533
http://purl.uniprot.org/citations/25170533http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25170533
http://purl.uniprot.org/uniprot/#_Q9C5Q8-mappedCitation-25170533http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25170533
http://purl.uniprot.org/uniprot/Q9C5Q8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25170533