| http://purl.uniprot.org/citations/25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25178844 | http://www.w3.org/2000/01/rdf-schema#comment | "Comparative Gene Identification-58 (CGI-58), as an adipose triglyceride lipase (ATGL) activator, strongly in-creases ATGL-mediated triglyceride (TG) catabolism. Previous studies have shown that CGI-58 affects intestinal cholesterol homeostasis independently of ATGL activity. Therefore, we hypothesized that CGI-58 was involved in macrophage cholesterol metabolism and consequently atherosclerotic lesion formation. Here, we generated macrophage-specific CGI-58 transgenic mice (Mac-CGI-58 Tg) using an SRA promoter, which was further mated with ApoE-/-mice to create litters of CGI-58 Tg/ApoE-/- mice. These CGI-58 Tg/ApoE-/-mice exhibited an anti-atherosclerosis phenotype compared with wild type (WT) controls (CGI-58 WT/ApoE-/-), illustrated by less plaque area in aortic roots. Moreover, macrophage-specific CGI-58 overexpression in mice resulted in upregulated levels of plasma total cholesterol and HDL-cholesterol. Consequently, higher expression levels of PPARa, PPARγ, LXRα, ABCA1, and ABCG1 were detected in macrophages from CGI-58 Tg/ApoE-/-mice compared to CGI-58 WT/ApoE-/-counterparts, which were accompanied by elevated macrophage cholesterol efflux toward HDL and Apo A1. Nevertheless, serum levels of TNF-α and IL-6 were reduced by macrophage-specific CGI-58 overexpression. Finally, bone marrow (BM) transplantation experiments further revealed that ApoE-/-mice reconstituted with Mac-CGI-58 Tg BM cells (ApoE-/-Tg-BM chimera) displayed a significant reduction of atherosclerosis lesions compared with control mice reconstituted with Mac-CGI-58 WT BM cells (ApoE-/-/WT-BM chimera). Collectively, these data strongly suggest that CGI-58 overexpression in macrophages may protect against atherosclerosis development in mice."xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbalip.2014.08.014"xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/author | "Sun B."xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/author | "Zeng X."xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/author | "Xiao J."xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/author | "Xie P."xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/pages | "1683-1690"xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/title | "Transgenic CGI-58 expression in macrophages alleviates the atherosclerotic lesion development in ApoE knockout mice."xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://purl.uniprot.org/core/volume | "1841"xsd:string |
| http://purl.uniprot.org/citations/25178844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25178844 |
| http://purl.uniprot.org/citations/25178844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25178844 |
| http://purl.uniprot.org/uniprot/#_D3Z7K3-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GX15-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_G3UWN5-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_G3UWW2-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_G3UZM8-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_H3BLJ0-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_H3BKV1-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_Q4FK40-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_Q3TX45-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |
| http://purl.uniprot.org/uniprot/#_Q3TXU4-mappedCitation-25178844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25178844 |