| http://purl.uniprot.org/citations/25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25179402 | http://www.w3.org/2000/01/rdf-schema#comment | "Epidermal growth factor (EGF) is known to play key roles in skin regeneration and wound-healing. Here, we demonstrate that Pep2-YAC, a tripeptide covering residues 29-31 in the B loop of EGF, promotes the proliferation of HaCaT keratinocytes with activity comparable to EGF. The treatment of HaCaT cells with Pep2-YAC induced phosphorylation, internalization, and degradation of EGFR and organization of signaling complexes, which consist of Grb2, Gab1, SHP2, and PI3K. In addition, it stimulated the phosphorylation of ERK1/2 at Thr 202/Tyr 204 and of Akt1 at Ser 473 and the nuclear translocation of EGFR, STAT3, c-Jun, and c-Fos. These results suggest that Pep2-YAC may be useful as a therapeutic agent for skin regeneration and wound-healing as an EGFR agonist."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.org/dc/terms/identifier | "doi:10.5483/bmbrep.2014.47.10.151"xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/author | "Hahn J.H."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/author | "Park K.H."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/author | "Lee K.J."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/author | "Kim Y.R."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/author | "Kim M.S."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/author | "Yoo Y.H."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/name | "BMB Rep"xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/pages | "581-586"xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/title | "YAC tripeptide of epidermal growth factor promotes the proliferation of HaCaT keratinocytes through activation of EGFR."xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/25179402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25179402 |
| http://purl.uniprot.org/citations/25179402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25179402 |
| http://purl.uniprot.org/uniprot/#_A0A068JD88-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_A8K2T7-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_A0A068JCC9-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F8-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F6-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9G5-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F1-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9G4-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |
| http://purl.uniprot.org/uniprot/#_B6RC66-mappedCitation-25179402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25179402 |