| http://purl.uniprot.org/citations/25179941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25179941 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundDuring retinal and spinal cord neurogenesis, Notch signaling plays crucial roles in regulating proliferation and differentiation of progenitor cells. One of the Notch ligands, Delta-like 4 (Dll4), has been shown to be expressed in subsets of retinal and spinal cord progenitors/precursors and involved in neuronal subtype specification. However, it remains to be determined whether Dll4 expression has any progenitor/precursor-specificity contributing to its functional specificity during neural development.ResultsWe generated a Dll4-Cre BAC transgenic mouse line that drives Cre recombinase expression mimicking that of the endogenous Dll4 in the developing retina and spinal cord. By fate-mapping analysis, we found that Dll4-expressing progenitors/precursors give rise to essentially all cone, amacrine and horizontal cells, a large portion of rod and ganglion cells, but only few bipolar and Müller cells. In the spinal cord, Dll4-expressing progenitors/precursors generate almost all V2a and V2c cells while producing only a fraction of the cells for other interneuron and motor neuron subtypes along the dorsoventral axis.ConclusionsOur data suggest that selective expression of Dll4 in progenitors/precursors contributes to its functional specificity in neuronal specification and that the Dll4-Cre line is a valuable tool for gene manipulation to study Notch signaling."xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.24185"xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/author | "Zou M."xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/author | "Xiang M."xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/pages | "86-97"xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/title | "Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord."xsd:string |
| http://purl.uniprot.org/citations/25179941 | http://purl.uniprot.org/core/volume | "244"xsd:string |
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