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| http://purl.uniprot.org/citations/25179963 | http://www.w3.org/2000/01/rdf-schema#comment | "All viruses require host cell factors to replicate. A large number of host factors have been identified that participate at numerous points of the human immunodeficiency virus 1 (HIV-1) life cycle. Recent evidence supports a role for components of the trans-Golgi network (TGN) in mediating early steps in the HIV-1 life cycle. The conserved oligomeric Golgi (COG) complex is a heteroctamer complex that functions in coat protein complex I (COPI)-mediated intra-Golgi retrograde trafficking and plays an important role in the maintenance of Golgi structure and integrity as well as glycosylation enzyme homeostasis. The targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication. This inhibition of HIV-1 replication preceded late reverse transcription (RT) but did not affect viral fusion. Silencing of the COG interacting protein the t-SNARE syntaxin 5, showed a similar defect in late RT product formation, strengthening the role of the TGN in HIV replication."xsd:string |
| http://purl.uniprot.org/citations/25179963 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virusres.2014.08.015"xsd:string |
| http://purl.uniprot.org/citations/25179963 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/25179963 | http://purl.uniprot.org/core/author | "Dykxhoorn D.M."xsd:string |
| http://purl.uniprot.org/citations/25179963 | http://purl.uniprot.org/core/author | "Dominska-Ngowe M."xsd:string |
| http://purl.uniprot.org/citations/25179963 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25179963 | http://purl.uniprot.org/core/name | "Virus Res"xsd:string |
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| http://purl.uniprot.org/citations/25179963 | http://purl.uniprot.org/core/title | "Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication."xsd:string |
| http://purl.uniprot.org/citations/25179963 | http://purl.uniprot.org/core/volume | "192"xsd:string |
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