| http://purl.uniprot.org/citations/25180700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25180700 | http://www.w3.org/2000/01/rdf-schema#comment | "This study investigated whether hypoxia-inducible factor (HIF)-1 influences postnatal vascularization and alveologenesis in mice and whether stable (constitutive-active) HIF could prevent hyperoxia-induced lung injury. We assessed postnatal vessel and alveolar formation in transgenic mice, expressing a stable, constitutive-active, HIF1α-subunit (HIF-1αΔODD) in the distal lung epithelium. In addition, we compared lung function, histology, and morphometry of neonatal transgenic and wild-type mice subjected to hyperoxia. We found that postnatal lungs of HIF-1αΔODD mice had a greater peripheral vessel density and displayed advanced alveolarization compared with control lungs. Stable HIF-1α expression was associated with increased postnatal expression of angiogenic factors, including vascular endothelial growth factor, angiopoietins 1 and 2, Tie2, and Ephrin B2 and B4. Hyperoxia-exposed neonatal HIF-1αΔODD mice exhibited worse lung function but had similar histological and surfactant abnormalities compared with hyperoxia-exposed wild-type controls. In conclusion, expression of constitutive-active HIF-1α in the lung epithelium was associated with increased postnatal vessel growth via up-regulation of angiogenic factors. The increase in postnatal vasculature was accompanied by enhanced alveolar formation. However, stable HIF-1α expression in the distal lung did not prevent hyperoxia-induced lung injury in neonates but instead worsened lung function."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2014-0037oc"xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Luo D."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Ackerley C."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Post M."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Tibboel D."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Caniggia I."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Tseu I."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "van Tuyl M."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "de Jongste J.C."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Selvaratnam J."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Groenman F.A."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/author | "Tibboel J."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/pages | "448-458"xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/title | "Hypoxia-inducible factor-1 stimulates postnatal lung development but does not prevent O2-induced alveolar injury."xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/25180700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25180700 |
| http://purl.uniprot.org/citations/25180700 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25180700 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-25180700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25180700 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-25180700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25180700 |