| http://purl.uniprot.org/citations/25186740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25186740 | http://www.w3.org/2000/01/rdf-schema#comment | "New granule cells are continuously integrated into hippocampal circuits throughout adulthood, and the fine-tuning of this process is likely important for efficient hippocampal function. During development, this integration process is critically regulated by the α-calcium/calmodulin-dependent protein kinase II (α-CaMKII), and here we ask whether this role is conserved in the adult brain. To do this, we developed a transgenic strategy to conditionally delete α-CaMKII from neural progenitor cells and their progeny in adult mice. First, we found that the selective deletion of α-CaMKII from newly generated dentate granule cells led to an increase in dendritic complexity. Second, α-CaMKII deletion led to a reduction in number of mature synapses and cell survival. Third, consistent with altered morphological and synaptic development, acquisition of one-trial contextual fear conditioning was impaired after deletion of α-CaMKII from newly generated dentate granule cells. Previous work in Xenopus identified α-CaMKII as playing a key role in the stabilization of dendritic and synaptic structure during development. The current study indicates that α-CaMKII plays a plays a similar, cell-autonomous role in the adult hippocampus and, in addition, reveals that the loss of α-CaMKII from adult-generated granule cells is associated with impaired hippocampus-dependent learning."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0652-14.2014"xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/author | "Elgersma Y."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/author | "Josselyn S.A."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/author | "Frankland P.W."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/author | "Restivo L."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/author | "Arruda-Carvalho M."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/author | "Epp J.R."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/author | "Guskjolen A."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/pages | "11919-11928"xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/title | "Conditional deletion of alpha-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning."xsd:string |
| http://purl.uniprot.org/citations/25186740 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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