| http://purl.uniprot.org/citations/25193656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25193656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25193656 | http://www.w3.org/2000/01/rdf-schema#comment | "Nef plays a major role in HIV-1 pathogenicity. We studied HIV-1 subtype C infected individuals in acute/early (n = 120) or chronic (n = 207) infection to investigate the relationship between Nef-mediated CD4/HLA-I down-regulation activities and disease progression, and the influence of immune-driven sequence variation on these Nef functions. A single Nef sequence per individual was cloned into an expression plasmid, followed by transfection of a T cell line and measurement of CD4 and HLA-I expression. In early infection, a trend of higher CD4 down-regulation ability correlating with higher viral load set point was observed (r = 0.19, p = 0.05), and higher HLA-I down-regulation activity was significantly associated with faster rate of CD4 decline (p = 0.02). HLA-I down-regulation function correlated inversely with the number HLA-associated polymorphisms previously associated with reversion in the absence of the selecting HLA allele (r = -0.21, p = 0.0002). These data support consideration of certain Nef regions in HIV-1 vaccine strategies designed to attenuate the infection course."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.08.009"xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.08.009"xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Carlson J."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Carlson J."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Reddy T."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Reddy T."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Walker B.D."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Walker B.D."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Williamson C."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Williamson C."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Brockman M.A."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Brockman M.A."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Brumme Z.L."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Brumme Z.L."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Goulder P.J."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Ndung'u T."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Ndung'u T."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Goulder P.J.R."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Chopera D."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Chopera D."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Mann J.K."xsd:string |
| http://purl.uniprot.org/citations/25193656 | http://purl.uniprot.org/core/author | "Mann J.K."xsd:string |