| http://purl.uniprot.org/citations/25193973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25193973 | http://www.w3.org/2000/01/rdf-schema#comment | "CaMKII was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. Here, we investigated the roles of different CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury by the use of new genetic CaMKII mouse models. Although CaMKIIδC was upregulated 1 day after I/R injury, cardiac damage 1 day after I/R was neither affected in CaMKIIδ-deficient mice, CaMKIIδ-deficient mice in which the splice variants CaMKIIδB and C were re-expressed, nor in cardiomyocyte-specific CaMKIIδ/γ double knockout mice (DKO). In contrast, 5 weeks after I/R, DKO mice were protected against extensive scar formation and cardiac dysfunction, which was associated with reduced leukocyte infiltration and attenuated expression of members of the chemokine (C-C motif) ligand family, in particular CCL3 (macrophage inflammatory protein-1α, MIP-1α). Intriguingly, CaMKII was sufficient and required to induce CCL3 expression in isolated cardiomyocytes, indicating a cardiomyocyte autonomous effect. We propose that CaMKII-dependent chemoattractant signaling explains the effects on post-I/R remodeling. Taken together, we demonstrate that CaMKII is not critically involved in acute I/R-induced damage but in the process of post-infarct remodeling and inflammatory processes."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.org/dc/terms/identifier | "doi:10.15252/emmm.201403848"xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Grone H.J."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Katus H.A."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Backs J."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Gretz N."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Hofmann K.P."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Nickel A."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Schneider M.D."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Sticht C."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Maack C."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Kreusser M.M."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Lehmann L.H."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Jungmann A."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Muller O.J."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Leuschner F."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Volz H.C."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Beckendorf J."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Diemert N."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Rostosky J.S."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Schreiter F.C."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/author | "Weinreuter M."xsd:string |
| http://purl.uniprot.org/citations/25193973 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |