| http://purl.uniprot.org/citations/25194920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25194920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25194920 | http://www.w3.org/2000/01/rdf-schema#comment | "The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nuclear import. In addition, a novel bipartite NLS was recently predicted at the C-terminal region of E1A in silico. In this study, we used immunofluorescence microscopy and co-immunoprecipitation analysis with importin-α to verify that full nuclear localization of E1A requires the well characterized NLS spanning residues 285-289, as well as a second basic patch situated between residues 258 and 263 ((258)RVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP(289)). Thus, the originally described NLS located at the C-terminus of E1A is actually a bipartite signal, which had been misidentified in the existing literature as a monopartite signal, altering our understanding of one of the oldest documented NLSs."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.08.014"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.08.014"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "King C.R."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "King C.R."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "Cohen M.J."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "Cohen M.J."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "Dikeakos J.D."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "Dikeakos J.D."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "Mymryk J.S."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/author | "Mymryk J.S."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/pages | "238-243"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/pages | "238-243"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/title | "Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/title | "Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal."xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/volume | "468"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://purl.uniprot.org/core/volume | "468"xsd:string |
| http://purl.uniprot.org/citations/25194920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25194920 |
| http://purl.uniprot.org/citations/25194920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25194920 |