| http://purl.uniprot.org/citations/25196196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25196196 | http://www.w3.org/2000/01/rdf-schema#comment | "DTNBP1 is a key candidate gene associated with schizophrenia. The expression of its protein product, dysbindin-1, is altered in the brains of schizophrenic patients; however, the physiological functions of dysbindin-1 in the central nervous system are unclear. Several studies have shown that both dysbindin-1 and histone deacetylase 3 (HDAC3) can be phosphorylated by the DNA-dependent protein kinase complex. In this study, we investigated the relationship between dysbindin-1 and HDAC3. We found that dysbindin-1 formed a protein complex with HDAC3 in human neuroblastoma cells and in mouse brain. The interaction between dysbindin-1 and HDAC3 occurred in an isoform-specific manner: HDAC3 coupled with dysbindin-1A and -1B, but not -1C. We also found that dysbindin-1B expression was increased in the nucleus in the presence of HDAC3, and, conversely, that the phosphorylation level of HDAC3 increased in the presence of dysbindin-1B. Taken together, these results identify a novel binding partner for dysbindin-1, which may potentially provide a new avenue for research into the neurological mechanisms of schizophrenia."xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2014.08.046"xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/author | "Ishiura S."xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/author | "Soma M."xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/author | "Suo S."xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/pages | "120-124"xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/title | "Dysbindin-1, a schizophrenia-related protein, interacts with HDAC3."xsd:string |
| http://purl.uniprot.org/citations/25196196 | http://purl.uniprot.org/core/volume | "582"xsd:string |
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