| http://purl.uniprot.org/citations/25196280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25196280 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural BH3-memitic (-)-gossypol shows promising antitumor efficacy in several kinds of cancer. However, our previous studies have demonstrated that protective autophagy decreases the drug sensitivities of Bcl-2 inhibitors in hepatocellular carcinoma (HCC) cells. In the present study, we are the first to report that Hsp90 inhibitor 17-AAG enhanced (-)-gossypol-induced apoptosis via suppressing (-)-gossypol-triggered protective autophagy and Mcl-1 accumulation. The suppression effect of 17-AAG on autophagy was mediated by inhibiting ERK-mediated Bcl-2 phosphorylation while was not related to Beclin1 or LC3 protein instability. Meanwhile, 17-AAG downregulated (-)-gossypol-triggered Mcl-1 accumulation by suppressing Mcl-1(Thr163) phosphorylation and promoting protein degradation. Collectively, our study indicates that Hsp90 plays an important role in tumor maintenance and inhibition of Hsp90 may become a new strategy for sensitizing Bcl-2-targeted chemotherapies in HCC cells."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2014.08.039"xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Dai X."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "He F."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Qin L."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Ni Z."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/author | "Lian J."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/pages | "379-387"xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/title | "Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://purl.uniprot.org/core/volume | "328"xsd:string |
| http://purl.uniprot.org/citations/25196280 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25196280 |
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| http://purl.uniprot.org/uniprot/#_B4DU51-mappedCitation-25196280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25196280 |
| http://purl.uniprot.org/uniprot/#_B4E3L8-mappedCitation-25196280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25196280 |