| http://purl.uniprot.org/citations/25196286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25196286 | http://www.w3.org/2000/01/rdf-schema#comment | "In lung cancer, the survival of patients with the same clinical stage varies widely for unknown reasons. In this two-phase study, we examined the hypothesis that germline variations influence the survival of patients with lung adenocarcinoma. First, we analyzed existing genotype and clinical data from 289 UK-resident patients with lung adenocarcinoma, identifying 86 single nucleotide polymorphisms (SNPs) that associated with survival (p < 0.01). We then genotyped these candidate SNPs in a validation series of 748 patients from Italy that resulted genetically compatible with the UK series based on principal component analysis. In a Cox proportional hazard model adjusted for age, sex and clinical stage, four SNPs were confirmed on the basis of their having a hazard ratio (HR) indicating the same direction of effect in the two series and p < 0.05. The strongest association was provided by rs2107561, an intronic SNP of PTPRG, protein tyrosine phosphatase, receptor type, G; the C allele was associated with poorer survival in both patient series (pooled analysis loge HR = 0.31; 95% CI: 0.15-0.46, p = 8.5 × 10(-5) ). PTPRG mRNA levels in 43 samples of lung adenocarcinoma were 40% of those observed in noninvolved lung tissue from the same patients. PTPRG overexpression significantly inhibited the clonogenicity of A549 lung carcinoma cells and the anchorage-independent growth of the NCI-H460 large cell lung cancer line. These four germline variants represent promising candidates that, with further study, may help predict clinical outcome. In addition, the PTPRG locus may have a role in tumor progression."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.29195"xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Iacobucci I."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Martinelli G."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Eisen T."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Houlston R.S."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Matakidou A."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Dragani T.A."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Frullanti E."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Colombo F."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Galvan A."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Pelosi G."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Incarbone M."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Pastorino U."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Sorio C."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Dugo M."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Santambrogio L."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Tosi D."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Tomasello L."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Nosotti M."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Noci S."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Alloisio M."xsd:string |
| http://purl.uniprot.org/citations/25196286 | http://purl.uniprot.org/core/author | "Vezzalini M."xsd:string |