| http://purl.uniprot.org/citations/25203353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25203353 | http://www.w3.org/2000/01/rdf-schema#comment | "Influenza virus infection induces several changes in host miRNA profile, host cell death and tissue damage. Cytochrome c is a regulator of the intrinsic apoptotic pathway and is altered during viral infections. Within the first 3h of infection with influenza virus, significant down-regulation of hsa-miRNA-4276 (miRNA-4276) is followed by a 2-fold increase in cytochrome c oxidase VIC (COX6C) mRNA was found to occur in human alveolar and bronchial epithelial cells. Expression of caspase-9 also increased within the first 3h of infection, but subsequently decreased. Modulation of miR-4276 using mimic and inhibitor oligonucleotides showed significant down-regulation or up-regulation, respectively, of COX6C expression. Our data suggests that on initial exposure to influenza virus, host cells upregulate COX6C mRNA expression through silencing miR-4276 and repressed viral replication by inducing the apoptotic protein caspase-9. Taken together, these data suggest that miR-4276 may be an important regulator of the early stages of infection by influenza."xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2014.08.007"xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/author | "Noti J.D."xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/author | "Beezhold D.H."xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/author | "Othumpangat S."xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/pages | "256-264"xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/title | "Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276."xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://purl.uniprot.org/core/volume | "468-470"xsd:string |
| http://purl.uniprot.org/citations/25203353 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25203353 |
| http://purl.uniprot.org/citations/25203353 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25203353 |
| http://purl.uniprot.org/uniprot/#_A0A024R9B7-mappedCitation-25203353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25203353 |
| http://purl.uniprot.org/uniprot/#_P09669-mappedCitation-25203353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25203353 |
| http://purl.uniprot.org/uniprot/A0A024R9B7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25203353 |
| http://purl.uniprot.org/uniprot/P09669 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25203353 |