| http://purl.uniprot.org/citations/25207809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25207809 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitination levels of protein substrates in eukaryotic cells are delicately orchestrated by various protein cofactors and enzymes. Dendritic cell-derived ubiquitin (Ub)-like protein (DC-UbP), also named as Ub domain-containing protein 2 (UBTD2), is a potential Ub shuttle protein comprised of a Ub-like (UbL) domain and a Ub-binding domain (UBD), but its biological function remains largely unknown. We identified two Ub-related enzymes, the deubiquitinating enzyme USP5 and the Ub-activating enzyme UbE1, as interacting partners of DC-UbP from HEK 293T cells. Biochemical studies revealed that the tandem UBA domains of USP5 and the C-terminal Ub-fold domain (UFD) of UbE1 directly interacted with the C-terminal UbL domain of DC-UbP but on the distinct surfaces. Overexpression of DC-UbP in HEK 293T cells enhanced the association of these two enzymes and thus prompted cellular ubiquitination, whereas knockdown of the protein reduced the cellular ubiquitination level. Together, DC-UbP may integrate the functions of USP5 and UbE1 through interacting with them, and thus reconcile the cellular ubiquitination and deubiquitination processes."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0107509"xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/author | "Gao Y.G."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/author | "Zhou C.J."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/author | "Zhang Y.H."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/author | "Hu H.Y."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/author | "Song A.X."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/pages | "e107509"xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/title | "A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes."xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25207809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25207809 |
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