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Subject | Predicate | Object |
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http://purl.uniprot.org/citations/25209151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/25209151 | http://www.w3.org/2000/01/rdf-schema#comment | "Within the framework of the EU-funded HLA-NET action, an analysis of three G-group alleles, HLA-B*44:02:01G, DRB1*14:01:01G and DQB1*03:01:01G, was undertaken in 12 European populations. Ambiguities were resolved by polymerase chain reaction-sequence-specific amplification (PCR-SSP) or PCR-sequence-based typing (PCR-SBT) in a total of 5095 individuals. The results of the DRB1*14:01/14:54 ambiguity showed high relative ratios (24-53%) of DRB1*14:01 in Bulgarians, Croatians, Greeks, Italians and Slovenians, contrasting with low ratios (6-13%) in Austrians, Finnish, French, Hungarians, Norwegians and Swiss. Resolution of the B*44:02/44:27 ambiguity showed that B*44:27 had a high relative ratio in Slovenians (25.5%) and Bulgarians (37%) and low in French and Swiss (0.02-1%), and was not observed in Greeks and Italians. The highest relative ratio of DQB1*03:19 was found in Portuguese (11%), by contrast with low ratios (0-3%) in the other five populations. Analysis of the A, B, DRB1 phenotypes and family-derived haplotypes in 1719 and 403 individuals positive for either HLA-B*44:02G or DRB1*14:01G ambiguities, respectively, showed some preferential associations, such as A*26∼DRB1*14:01, B*35∼DRB1*14:01, B*38∼DRB1*14:01 and B*44:27∼DRB1*16. Because these ambiguities are located outside the peptide-binding site, they may not be recognized by alloreactive T-cells. However, because of strong linkage disequilibrium (LD), the DRB1*14:01 vs DRB1*14:54 and the B*44:02 vs B*44:27 mismatches are associated to DRB3-, and C-mismatches, respectively. These results are informative for algorithms searching unrelated hematopoietic stem cell donors. For B*44:27-positive patients, searches are expected to be more successful when requesting donors from Southeastern-European ancestry. Furthermore, the introduction of human leukocyte antigen (HLA)-typing strategies that allow resolving exon 4 (for class I) and exon 3 (for class II) polymorphisms can be expected to contribute significantly to population genetics studies."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.org/dc/terms/identifier | "doi:10.1111/tan.12422"xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Tordai A."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Viken M.K."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Lokki M.L."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Buhler S."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Dubois V."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Grubic Z."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Jaatinen T."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Poli F."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Sanchez-Mazas A."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Tiercy J.M."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Wenda S."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Vidan-Jeras B."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Ligeiro D."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Papasteriades C."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Nunes J.M."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Ivanova M."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/author | "Spyropoulou-Vlachou M."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/pages | "459-464"xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/title | "Resolution of HLA-B*44:02:01G, -DRB1*14:01:01G and -DQB1*03:01:01G reveals a high allelic variability among 12 European populations."xsd:string |
http://purl.uniprot.org/citations/25209151 | http://purl.uniprot.org/core/volume | "84"xsd:string |