| http://purl.uniprot.org/citations/25210797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25210797 | http://www.w3.org/2000/01/rdf-schema#comment | "Che-1/AATF is an RNA polymerase II-binding protein that is involved in the regulation of gene transcription, which undergoes stabilization and accumulation in response to DNA damage. We have previously demonstrated that following apoptotic induction, Che-1 protein levels are downregulated through its interaction with the E3 ligase HDM2, which leads to Che-1 degradation by ubiquitylation. This interaction is mediated by Pin1, which determines a phosphorylation-dependent conformational change. Here we demonstrate that HIPK2, a proapoptotic kinase, is involved in Che-1 degradation. HIPK2 interacts with Che-1 and, upon genotoxic stress, phosphorylates it at specific residues. This event strongly increases HDM2/Che-1 interaction and degradation of Che-1 protein via ubiquitin-dependent proteasomal system. In agreement with these findings, we found that HIPK2 depletion strongly decreases Che-1 ubiquitylation and degradation. Notably, Che-1 overexpression strongly counteracts HIPK2-induced apoptosis. Our results establish Che-1 as a new HIPK2 target and confirm its important role in the cellular response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2014.381"xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Camerini S."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Crescenzi M."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Iezzi S."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Passananti C."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Soddu S."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Rinaldo C."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Desantis A."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Sorino C."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/author | "Catena V."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/pages | "e1414"xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/title | "HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation."xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25210797 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25210797 |
| http://purl.uniprot.org/citations/25210797 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25210797 |
| http://purl.uniprot.org/uniprot/#_A4D1R9-mappedCitation-25210797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25210797 |
| http://purl.uniprot.org/uniprot/#_Q9H2X6-mappedCitation-25210797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25210797 |