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| http://purl.uniprot.org/citations/25212464 | http://www.w3.org/2000/01/rdf-schema#comment | "Animal studies have shown that decreased orexin expression changes sleep regulation with normal aging. This study examined orexin A and B expression in the tuberal hypothalamus in infants (0-1 year; n = 8), children (4-10 years; n = 7), young adults (22-32 years; n = 4), and older (48-60 years; n = 7) adults. Neuronal expression was defined by the percentage positive orexin immunoreactive (Ox-ir) neurons in the whole tuberal hypothalamus, and in the dorsal medial (DMH), perifornical, and lateral hypothalamus. In addition, the number of Ox-ir neurons/mm(2), regional distribution, and co-localization were examined. Within the whole tuberal hypothalamic section, there was a 23% decrease in the percentage of Ox-ir neurons between infants and older adults (p < 0.001), and a 10% decrease in older compared with younger adults (p = 0.023). These changes were confined to the DMH and/or perifornical hypothalamus. There was a 9%-24% decrease in Ox neurons/mm(2) in adults compared with infants and/or children (p ≤ 0.001). These results demonstrate a decrease in Ox expression with normal human maturation and aging. This may contribute to changes in sleep regulation during development and with aging."xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2014.08.010"xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/author | "Waters K.A."xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/author | "Rodriguez M.L."xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/author | "Machaalani R."xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/author | "Hunt N.J."xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/pages | "292-300"xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/title | "Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus."xsd:string |
| http://purl.uniprot.org/citations/25212464 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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